Dr. Fetus + Brimstone
Partial / overridden
Brimstone overrides Dr. Fetus. The player turns black but the Top hat and Monocle from Dr. Fetus still remain.
Synergies (Original game)
69 documented item interactions.
⌕
Dr. Fetus + Chocolate Milk
Partial / overridden
Cancels the Chocolate Milk affect. There is only a graphical glitch which makes Isaac look like he is spitting bombs out his mouth.
Dr. Fetus + Common Cold
Partial / overridden
Graphical changes only. Isaac's head and the bombs from Dr. Fetus turn green but the explosion does not cause any poison affect on enemies.
Dr. Fetus + Epic Fetus
Partial / overridden
Epic Fetus overrides Dr. Fetus.
Dr. Fetus + The Inner Eye
Does not work
Greatly decreases the fire rate of bombs down to one bomb about every 4 seconds. Additionally, the damage of each bomb does not increase.
Dr. Fetus + IPECAC
Does not work
Greatly decreases the fire rate of bombs down to one bomb about every 4 seconds. Additionally, the damage of each bomb does not increase and Dr. Fetus bombs do not get a poison effect.
Dr. Fetus + Mutant Spider
Does not work
Greatly decreases the fire rate of bombs down to one bomb about every 4 seconds. Additionally, the damage of each bomb does not increase.
Dr. Fetus + Mom's Contacts
Partial / overridden
Turns Dr. Fetus bombs red but does not give them the freeze effect from Mom's Contacts.
Dr. Fetus + Mom's Knife
Partial / overridden
Mom's Knife overrides Dr. Fetus. Top hat and Monocle from Dr. Fetus still remain.
Dr. Fetus + Number One
Works great
Greatly increases the rate of fire of bombs from Dr. Fetus and turns each bomb yellow.
Dr. Fetus + Polyphemus
Partial / overridden
Greatly decreases the fire rate of bombs down to one bomb about every 4 seconds but increases the damage of each bomb by almost double.
Dr. Fetus + Sacred Heart
Works great
Slightly decreases the fire rate of Dr. Fetus bombs, gives them a homing effect and increases damage by about x1.2.
Dr. Fetus + Spider Bite
Partial / overridden
Does not add the slowing effect from Spider's Bite to the Dr. Fetus bombs.
Dr. Fetus + Spoon Bender
Works great
Turns Dr. Fetus bombs purple and gives them a homing effect.
Dr. Fetus + Technology
Partial / overridden
Dr. Fetus overrides Technology. The technology laser appears to still fire however this is simply a graphical glitch and does no damage.
Dr. Fetus + Technology 2
Works great
The player will fire the Technology 2 laser and the Dr. Fetus bombs together.
Dr. Fetus + Wiggle Worm
Works great
Wiggle Worm causes Mom's Knife to move in a wiggling fashion across the screen and also makes the knife charge quicker very slightly.
Brimstone + Chocolate Milk
Does not work
Chocolate Milk allows you to release non-fully charged Brimstone shots which do less damage. The damage per laser scales linearly to 100% damage at 2 seconds of charge. If you pre-charge Brimstone before entering another room, the Chocolate Milk will make the first shot do no damage. Chocolate Milk also prevents use of the Brimstone Glitch.
Brimstone + Common Cold
Works great
Brimstone shots have a chance to apply the poison effect from the Common Cold.
Brimstone + Epic Fetus
Partial / overridden
Epic Fetus overrides Brimstone and you do not retain the x3 damage from Brimstone shots.
Brimstone + Dr. Fetus
Partial / overridden
Brimstone overrides Dr. Fetus with no other stat changes.
Brimstone + The Inner Eye
Works great
Brimstone overrides Triple shot, but Brimstone shots now do 300% damage and take a much longer time to charge. The damage x3 effects of Ipecac and Mutant Spider on Brimstone do not stack with the Inner Eye's x3 multiplier.
Brimstone + IPECAC
Works great
Brimstone overrides Ipecac, but Brimstone shots now do 300% damage and take a much longer time to charge. The damage x3 effects of Inner Eye and Mutant Spider on Brimstone do not stack with the Ipecac's x3 multiplier.
Brimstone + Mutant Spider
Works great
Brimstone overrides Mutant Spider, but Brimstone shots now do 300% damage and take a much longer time to charge. The damage x3 effects of Inner Eye and Ipecac on Brimstone do not stack with the Mutant Spider's x3 multiplier. If you have Brimstone and Polyphemus, you do NOT want to take Mutant Spider, as it would reduce your damage by roughly half.
Brimstone + Mom's Contacts
Works great
Mom's Contacts applies the freeze effect to Brimstone shots.
Brimstone + Mom's Knife
Partial / overridden
Mom's Knife overrides Brimstone.
Brimstone + Number One
Partial / overridden
Number One has no effect on Brimstone. Number One is also a special item, so picking it up would give you less chance to pick up other good 'special' items. For more information about special items, check the FAQ page.
Brimstone + Polyphemus
Works great
Polyphemus causes Brimstone to do massive damage and makes the charge time on the laser significantly longer. The big increase in charge time is worth it with Polyphemus because having just these two items causes the Brimstone beam to do 135, instead of the usual 10.5 damage. This huge increase in damage will one shot most bosses and becomes even more powerful with the Brimstone Glitch. In this situation you do NOT want to take Mutant Spider, as it would reduce your damage by roughly half.
Brimstone + Sacred Heart
Works great
Sacred Heart causes the Brimstone laser to do significantly more damage, however it will take slightly longer to charge.
Brimstone + Spider Bite
Works great
Brimstone shots now have a random chance to apply the slowing effect from Spider's Bite.
Brimstone + Spoon Bender
Partial / overridden
Spoon Bender has no effect on Brimstone shots. Spoon Bender is also a special item, so picking it up would give you less chance to pick up other good 'special' items. For more information about special items, check the FAQ page.
Brimstone + Technology
Partial / overridden
Brimstone overrides Technology.
Brimstone + Technology 2
Partial / overridden
Both the Technology 2 and Brimstone lasers will fire together. The Brimstone laser is affected by the -35% damage down from Technology 2, however this combination is probably a damage per second increase due to the stacking of both lasers.
Brimstone + Wiggle Worm
Partial / overridden
Wiggle worm has no effect on Technology 2 lasers, however normal shots will still fire alongside with a wiggle effect.
IPECAC + Brimstone
Partial / overridden
Brimstone overrides Ipecac, but Brimstone shots now do 300% damage and take a much longer time to charge. The damage x3 effects of Inner Eye and Mutant Spider on Brimstone do not stack with the Ipecac's x3 multiplier.
IPECAC + Chocolate Milk
Works great
Chocolate Milk allows you to charge Ipecac shots which do slightly more damage compared to uncharged shots. Ipecac shots will no longer automatically fire if you hold down the arrow key, so if you dislike charged shots then do not take Chocolate Milk here.
IPECAC + Common Cold
Partial / overridden
The Common Cold has no effect on Ipecac shots. Common Cold is also a special item, so you may wish to not take it if you already have Ipecac.
IPECAC + Epic Fetus
Partial / overridden
Epic Fetus overrides Ipecac.
IPECAC + Dr. Fetus
Does not work
Dr. Fetus overrides Ipecac. Ipecac also severely decreases the fire rate of Dr. Fetus bombs.
IPECAC + The Inner Eye
Partial / overridden
The Inner Eye has no effect on Ipecac shots or their fire rate.
IPECAC + Mutant Spider
Partial / overridden
Mutant Spider has no effect on Ipecac shots or their fire rate.
IPECAC + Mom's Contacts
Works great
Mom's Contacts causes Ipecac shots to have a random chance to freeze enemies to stone for a few seconds. Having enemies frozen in place is extremely useful for aiming Ipecac shots.
IPECAC + Mom's Knife
Partial / overridden
Mom's Knife overrides Ipecac.
IPECAC + Number One
Works great
Number One greatly increases the fire rate and range of Ipecac shots. Having decreased range allows Ipecac shots to be aimed more easily.
IPECAC + Polyphemus
Works great
Polyphemus increases the damage of Ipecac shots slightly (53.5 damage vs. 65 damage) but does not slow down the fire rate at all. In this situation you do not want to take the Mutant Spider, as it would slightly reduce your damage.
IPECAC + Sacred Heart
Works great
Sacred Heart gives Ipecac shots a homing effect which causes them to curve towards enemies, improving accuracy. Sacred Heart also very slightly increases the damage and decreases the range of each Ipecac shot. Having decreased range allows Ipecac shots to be aimed more easily.
IPECAC + Spider Bite
Works great
Ipecac shots now have a random chance to slow enemy speed and shot speed if the Spider's Bite effect activates.
IPECAC + Spoon Bender
Works great
Ipecac shots gain the Spoon Bender effect, which causes them to curve towards enemies and improves accuracy.
IPECAC + Technology
Partial / overridden
Technology 1 overrides Ipecac and causes the laser to do 300% damage. The x3 damage multiplier from Ipecac does not stack with the other x3 damage multipliers from The Inner Eye and Mutant Spider.
IPECAC + Technology 2
Partial / overridden
Both Technology 2 and Ipecac shots will fire together and the damage of the laser will be slightly increased. The -35% damage from Tech 2 barely effects the damage of the ipecac shots (reduces from 53.5 to just over 52.5, not much difference).
IPECAC + Wiggle Worm
Works great
Wiggle Worm causes Ipecac shots to wiggle as they travel through the air.
Guppy + Brimstone
Works great
Having Brimstone as Guppy causes blue flies to spawn each time the Brimstone laser ticks and the flies are not affected by the x3 damage multiplier that Brimstone gives. Also, if you are using the Brimstone Glitch, a fly will spawn each time the glitch hits an enemy, which can cause up to three more flies to spawn per Brimstone laser.
Guppy + Chocolate Milk
Works great
Charged shots from the Chocolate Milk will cause Guppy flies to do a lot more damage. Additionally, the Guppy sprite will not show how charged your shots currently are.
Guppy + Common Cold
Works great
The Common Cold effect still works with normal tears when you are Guppy the Cat.
Guppy + Epic Fetus
Partial / overridden
Epic Fetus overrides normal tears, therefore your fired missiles will not spawn blue flies each time they hit. You still retain the flying ability from Guppy state and your player sprite will be a flying cat with a top hat.
Guppy + Dr. Fetus
Partial / overridden
Dr. Fetus overrides normal tears, therefore your fired bombs will not spawn blue flies each time they hit. You still retain the flying ability from Guppy state and your player sprite will be a flying cat with a top hat.
Guppy + The Inner Eye
Works great
Each of the tears from your Triple Shot which hits an enemy will cause you to spawn a blue fly. The damage that each fly does is not increased as a result of the Inner Eye.
Guppy + IPECAC
Works great
Ipecac stacks with Guppy and each poison ipecac shot has a chance for blue flies to spawn.
Guppy + Mutant Spider
Works great
Each of the tears from your Quad Shot which hits an enemy will cause you to spawn a blue fly. The damage that each fly does is not increased as a result of the Mutant Spider.
Guppy + Mom's Contacts
Works great
Your normal tears have a random chance to apply the freeze effect from Mom's Contacts and will also continue to spawn blue flies.
Guppy + Mom's Knife
Works great
Mom's Knife replaces your normal tears and spawns lots of blue flies each time you hit an enemy with it. Blue flies spawned this way will not get a damage increase as a result of Mom's Knife
Guppy + Number One
Works great
The tears up from Number one stacks with Guppy and will cause you to fire low range tears but a lot more frequently, which will cause more blue flies to spawn.
Guppy + Polyphemus
Works great
Polyphemus stacks with Guppy state and each blue fly spawned will do double the damage that your tears do. At base damage Polyphemus tears do 15 damage and therefore blue flies do 30 damage, which makes this an extremely powerful item synergy.
Guppy + Sacred Heart
Works great
Sacred Heart stacks with Guppy state and each blue fly spawned will do double the damage that your tears do. At base damage Sacred Heart tears do ~9 damage and therefore blue flies do 18 damage, which makes this a powerful item synergy.
Guppy + Spider Bite
Works great
Normal tears have a random chance to apply the Spider's Bite effect, which will slow down enemy speed and shot speed.
Guppy + Spoon Bender
Works great
Normal tears get the Spoon Bender effect, which makes them curve towards enemies.
Guppy + Technology
Works great
Normal tears become lasers and each laser which hits an enemy will spawn a blue fly from the Guppy effect. Isaac's player sprite will lose his cat head and replace it with the normal technology head.
Guppy + Technology 2
Works great
The very high fire rate of Technology 2 will cause significantly more blue flies to spawn. The -35% damage from Technology 2 applies to each blue fly, however this combination spawns so many flies that it more than makes up for the damage decrease.
Guppy + Wiggle Worm
Works great
Isaac's tears gain the wiggle effect from Wiggle Worm and get a small fire rate increase. Blue flies spawn exactly the same as they do with normal Guppy state.
No matches.